BioEssays 1∕2014

What fuels appendage regeneration? On pages 27‐32 of this issue, Love et al. examine the role of carbohydrate metabolism during vertebrate appendage regeneration. The authors largely focus their examination on recent studies using the Xenopus model, whose tadpoles and froglets (shown on the cover, tissues visualized with immunostaining and transgenesis) have the impressive ability to regenerate some of their appendages. The authors argue that increasing carbohydrate entry into anabolic pathways is critical to the regeneration program and that Xenopus represents a good model system to study the interplay between cellular metabolism and appendage regeneration. Cover by Nick R. Love.