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Distinct mechanisms determine organ left‐right asymmetry patterning in an uncoupled way
Author(s) -
Huang Sizhou,
Xu Wenming,
Su Bingyin,
Luo Lingfei
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201300128
Subject(s) - nodal , mesoderm , biology , asymmetry , process (computing) , anatomy , lateral plate mesoderm , microbiology and biotechnology , neuroscience , computer science , physics , genetics , embryonic stem cell , gene , operating system , quantum mechanics
Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left‐right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning. Also watch the Video Abstract .