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How do I kill thee? Let me count the ways: p53 regulates PARP ‐1 dependent necrosis
Author(s) -
Elkholi Rana,
Chipuk Jerry E.
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201300117
Subject(s) - poly adp ribose polymerase , dna damage , dna repair , biology , cell cycle checkpoint , apoptosis , microbiology and biotechnology , senescence , cancer research , cell cycle , function (biology) , suppressor , gene , genome instability , polymerase , dna , genetics
Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome integrity, cancer development, and cancer treatment has intrigued scientists and clinicians for decades. It appears that the p53 pathway is a central node for nearly all cell stress responses, including: gene expression, DNA repair, cell cycle arrest, metabolic adjustments, apoptosis, and senescence. In the past decade, it has become increasingly clear that p53 function is directly regulated by poly(ADP‐ribose) polymerase‐1 (PARP‐1), a nuclear enzyme involved in DNA repair signaling. Here, we will discuss the impact of PARP‐1 on p53 function, along with a recently described novel role for the reciprocal regulation of p53 regulated, PARP‐1 dependent necrosis following DNA damage.