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Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development
Author(s) -
Skoblov Mikhail,
Marakhonov Andrey,
Marakasova Ekaterina,
Guskova Anna,
Chandhoke Vikas,
Birerdinc Aybike,
Baranova Ancha
Publication year - 2013
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201300002
Subject(s) - biology , cytokinesis , rheb , chromatin , microbiology and biotechnology , rhoa , nedd8 , protein family , regulator , tor signaling , pi3k/akt/mtor pathway , ubiquitin ligase , ubiquitin , computational biology , signal transduction , genetics , cell , dna , cell division , gene , mtorc1
The KCTD family includes tetramerization (T1) domain containing proteins with diverse biological effects. We identified a novel member of the KCTD family, BTBD10. A comprehensive analysis of protein‐protein interactions (PPIs) allowed us to put forth a number of testable hypotheses concerning the biological functions for individual KCTD proteins. In particular, we predict that KCTD20 participates in the AKT‐mTOR‐p70 S6k signaling cascade, KCTD5 plays a role in cytokinesis in a NEK6 and ch‐TOG‐dependent manner, KCTD10 regulates the RhoA/RhoB pathway. Developmental regulator KCTD15 represses AP‐2α and contributes to energy homeostasis by suppressing early adipogenesis. TNFAIP1‐like KCTD proteins may participate in post‐replication DNA repair through PCNA ubiquitination. KCTD12 may suppress the proliferation of gastrointestinal cells through interference with GABAb signaling. KCTD9 deserves experimental attention as the only eukaryotic protein with a DNA‐like pentapeptide repeat domain. The value of manual curation of PPIs and analysis of existing high‐throughput data should not be underestimated.