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tRNA modifications: Necessary for correct tRNA‐derived fragments during the recovery from stress?
Author(s) -
Durdevic Zeljko,
Schaefer Matthias
Publication year - 2013
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200158
Subject(s) - transfer rna , endonuclease , fragmentation (computing) , biology , translation (biology) , microbiology and biotechnology , t arm , protein biosynthesis , genetics , rna , messenger rna , dna , gene , ecology
Endonuclease‐mediated tRNA fragmentation has been observed in many species suggesting functional importance for tRNA fragments. The size distribution of tRNA‐derived fragments indicates the existence of mechanisms that protect tRNAs and their fragments from total degradation by exonucleases. Could post‐transcriptional modifications be important for the controlled processing of tRNAs?