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How winner cells cause the demise of loser cells
Author(s) -
Lolo FidelNicolás,
Tintó Sergio Casas,
Moreno Eduardo
Publication year - 2013
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200156
Subject(s) - demise , microbiology and biotechnology , biology , competition (biology) , population , cell , programmed cell death , immunology , genetics , apoptosis , medicine , political science , ecology , environmental health , law
Recent results show that, during the process known as cell competition, winner cells identify and kill viable cells from a growing population without requiring engulfment. The engulfment machinery is mainly required in circulating macrophages (hemocytes) after the discrimination between winners and losers is completed and the losers have been killed and extruded from the epithelium. Those new results leave us with the question as to which molecules allow winner cells to recognize and impose cell death on the loser cells during cell competition.