Premium
The nuclear import machinery is a determinant of influenza virus host adaptation
Author(s) -
ResaInfante Patricia,
Gabriel Gülsah
Publication year - 2013
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200138
Subject(s) - nuclear transport , biology , virology , microbiology and biotechnology , viral envelope , viral replication , host (biology) , polymerase , influenza a virus , influenza a virus subtype h5n1 , viral entry , nuclear export signal , adaptation (eye) , virus , cell nucleus , genetics , nucleus , gene , neuroscience
After viral entry into the cell, the nuclear envelope poses a major cellular barrier that needs to be overcome upon adaptation of highly pathogenic avian influenza viruses (HPAIV) to the new host. To ensure efficient viral transcription and replication in the nucleus of the host cell, the viral polymerase complex of avian influenza viruses needs to switch from recognition of avian to mammalian components of the nuclear import machinery. Recent evidence suggests that influenza viruses have evolved different mechanisms to utilize importin‐α isoforms as components of this machinery, bridging pre‐ and post‐nuclear import on both sides of the nuclear envelope.