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Ohno's hypothesis and Muller's paradox: Sex chromosome dosage compensation may serve collective gene functions
Author(s) -
Forsdyke Donald R.
Publication year - 2012
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200103
Subject(s) - dosage compensation , heterogametic sex , biology , gene dosage , gene , genetics , mendelian inheritance , x chromosome , x inactivation , skewed x inactivation , allele , chromosome , gene expression
Muller found halving gene dosage, as in males with one X chromosome, did not affect specific gene function. Why then was dosage “compensated?” This paradox was solved by invoking collective gene functions such as self/not self discrimination afforded by protein aggregation pressure. This predicts female susceptibility to autoimmune disease.