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Are expression profiles meaningless for cancer studies?
Author(s) -
Jordan Bertrand
Publication year - 2012
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200074
Subject(s) - expression (computer science) , computational biology , biology , evolutionary biology , data science , computer science , programming language
Expression signatures obtained from tumour samples are widely used to characterise tumour subtypes and to provide prognostic information. This commentary, based on a recent paper, questions the scientific validity of such signatures as a means of understanding the underlying biology.