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Longevity and the long arm of epigenetics: Acquired parental marks influence lifespan across several generations
Author(s) -
Pang Shanshan,
Curran Sean P.
Publication year - 2012
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200046
Subject(s) - longevity , epigenetics , biology , evolutionary biology , genetics , demography , sociology , gene
A recent study reported that longevity in Caenorhabditits elegans can be inherited over several generations. This is probably achieved through the following epigenetic mechanism: inherited demethylated histones at some central loci, such as miRNA, transcription factors or signaling regulators affect the expression of certain genes leading to the longevity phenotype.