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Domain shuffling and the increasing complexity of biological networks
Author(s) -
de Souza Sandro J.
Publication year - 2012
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200006
Subject(s) - shuffling , interconnectivity , domain (mathematical analysis) , dna shuffling , computational biology , protein evolution , computer science , protein domain , process (computing) , biology , topology (electrical circuits) , genetics , directed evolution , mathematics , gene , artificial intelligence , combinatorics , mutant , mathematical analysis , programming language , operating system
Domains can spread among proteins in a process called domain shuffling and this has been identified as one of the major mechanisms leading to the formation of new proteins throughout evolution. This process has an impact on the topology of protein‐protein interaction networks as it may create new hubs and also increase interconnectivity.