Premium
Why does the immune system of Atlantic cod lack MHC II?
Author(s) -
Star Bastiaan,
Jentoft Sissel
Publication year - 2012
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201200005
Subject(s) - major histocompatibility complex , biology , immune system , acquired immune system , vertebrate , context (archaeology) , gadus , atlantic cod , evolutionary biology , immunology , genetics , gene , fish <actinopterygii> , paleontology , fishery
MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll‐like receptors (TLRs).