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BioEssays 11/2011
Publication year - 2011
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201190062
Subject(s) - induced pluripotent stem cell , citation , embryonic stem cell , novelty , computer science , stem cell , phenotype , computational biology , artificial intelligence , biology , machine learning , genetics , gene , world wide web , psychology , social psychology
FBW7 in cancer drug resistance. The occurrence of resistance to chemotherapeutic agents constitutes a major problem in cancer treatment. In their article on pages 851‐859 , Wang et al. elucidate the role of the F‐box and WD repeat domain‐containing 7 (FBW7) tumor suppressor in this process. On one hand, FBW7‐deficient cells are addicted to the elevated levels of the Mcl‐1 pro‐survival factor, rendering these cells more sensitive to the chemotherapeutic drug sorafenib. On the other hand, in the absence of this protein, taxol‐ and vincristineinduced cell death is inhibited. Furthermore, inhibition of tumor growth by ABT‐737 and gamma secretase inhibitor (GSI) is impaired. Because of its central role in cancer drug resistance, targeting of FBW7 may open a new therapeutic window for drug administration.Backcover by Z. Wang and W. Wei