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Towards cracking the epigenetic code using a combination of high‐throughput epigenomics and quantitative mass spectrometry‐based proteomics
Author(s) -
Stunnenberg Hendrik G.,
Vermeulen Michiel
Publication year - 2011
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201100044
Subject(s) - epigenomics , proteomics , computational biology , context (archaeology) , epigenetics , mass spectrometry , computer science , genomics , metabolomics , throughput , chromatin , biology , bioinformatics , chemistry , dna methylation , genome , genetics , chromatography , dna , gene , paleontology , telecommunications , gene expression , wireless
High‐throughput genomic sequencing and quantitative mass spectrometry (MS)‐based proteomics technology have recently emerged as powerful tools, increasing our understanding of chromatin structure and function. Both of these approaches require substantial investments and expertise in terms of instrumentation, experimental methodology, bioinformatics, and data interpretation and are, therefore, usually applied independently from each other by dedicated research groups. However, when applied reiteratively in the context of epigenetics research these approaches are strongly synergistic in nature.