Premium
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?
Author(s) -
Skeldal Sune,
Matusica Dusan,
Nykjaer Anders,
Coulson Elizabeth J.
Publication year - 2011
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201100036
Subject(s) - neurotrophin , trk receptor , low affinity nerve growth factor receptor , receptor , microbiology and biotechnology , biology , growth cone , neuroscience , intracellular , genetics , axon
The common neurotrophin receptor (p75 NTR ) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75 NTR ‐mediated signals following activation by either mature or pro‐neurotrophins and in combination with various co‐receptors, including Trk receptors and sortilin. Here, we review the known functions of p75 NTR by cell type, receptor‐ligand combination, and whether regulated intra‐membrane proteolysis of p75 NTR is required for signalling. We highlight that the generation of the intracellular domain fragment of p75 NTR is associated with many of the receptor functions, regardless of its ligand and co‐receptor interactions.