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Making new out of old: Recycling and modification of an ancient protein translocation system during eukaryotic evolution
Author(s) -
Bolte Kathrin,
Gruenheit Nicole,
Felsner Gregor,
Sommer Maik S.,
Maier UweG.,
Hempel Franziska
Publication year - 2011
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201100007
Subject(s) - endoplasmic reticulum , endoplasmic reticulum associated protein degradation , chromosomal translocation , biology , ubiquitin , plastid , microbiology and biotechnology , evolutionary biology , computational biology , genetics , unfolded protein response , gene , chloroplast
At first glance the three eukaryotic protein translocation machineries – the ER‐associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre‐protein translocator of complex plastids – appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre‐existing components as an effective evolutionary driving force. Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract