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Control of DNA replication: A new facet of Hox proteins?
Author(s) -
Miotto Benoit,
Graba Yacine
Publication year - 2010
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201000048
Subject(s) - hox gene , replication (statistics) , biology , dna replication , microbiology and biotechnology , facet (psychology) , transcription factor , transcription (linguistics) , origin recognition complex , dna replication factor cdt1 , genetics , computational biology , control of chromosome duplication , dna , eukaryotic dna replication , gene , psychology , virology , social psychology , linguistics , philosophy , personality , big five personality traits
Hox proteins are well‐known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox‐mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.