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BioEssays 3/2009
Author(s) -
Tompa Peter,
Fuxreiter Monika,
Oldfield Christopher J.,
Simon Istvan,
Dunker A. Keith,
Uversky Vladimir N.
Publication year - 2009
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.200990014
Subject(s) - domain (mathematical analysis) , sequence (biology) , thymosin , cover (algebra) , actin , peptide sequence , computational biology , extension (predicate logic) , public domain , biology , microbiology and biotechnology , computer science , genetics , biochemistry , gene , engineering , geography , mathematics , mechanical engineering , mathematical analysis , programming language , archaeology
Cover Photograph: Structure of the actin‐regulatory protein thymosin‐beta4 (gold) in complex with G‐actin (grey). The amino acid sequence corresponding to thymosin beta4 also appears as part of other proteins, when it is termed the WH2 domain. The domain, as also suggested by its extended conformation in the complex, is intrinsically disordered in isolation. Such examples call upon the extension of the domain concept of proteins, as discussed in the article by Tompa et al. (on pages 328‐335).