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Dynamic network rewiring determines temporal regulatory functions in Drosophila melanogaster development processes
Author(s) -
Kim ManSun,
Kim JeongRae,
Cho KwangHyun
Publication year - 2010
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.200900169
Subject(s) - biological network , network motif , gene regulatory network , sequence (biology) , drosophila melanogaster , identification (biology) , computer science , network analysis , computational biology , dynamic network analysis , sequence motif , biology , gene , genetics , gene expression , computer network , botany , physics , quantum mechanics
The identification of network motifs has been widely considered as a significant step towards uncovering the design principles of biomolecular regulatory networks. To date, time‐invariant networks have been considered. However, such approaches cannot be used to reveal time‐specific biological traits due to the dynamic nature of biological systems, and hence may not be applicable to development, where temporal regulation of gene expression is an indispensable characteristic. We propose a concept of a “temporal sequence of network motifs”, a sequence of network motifs in active sub‐networks constructed over time, and investigate significant network motifs in the active temporal sub‐networks of Drosophila melanogaster . Based on this concept, we find a temporal sequence of network motifs which changes according to developmental stages and thereby cannot be identified from the whole static network. Moreover, we show that the temporal sequence of network motifs corresponding to each developmental stage can be used to describe pivotal developmental events.