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Stripe formation in the early fly embryo: principles, models, and networks
Author(s) -
Papatsenko Dmitri
Publication year - 2009
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.200900096
Subject(s) - zygote , embryo , biology , embryogenesis , gene regulatory network , gene , microbiology and biotechnology , computational biology , maternal to zygotic transition , gene expression , drosophila embryogenesis , evolutionary biology , genetics
Early development of animal embryos begins from spatially distributed products of gene expression, i.e. , gradients. While maternal and early zygotic genes form broad and/or terminal gradients, their direct targets appear later on as relatively narrow stripes, which foreshadow presumptive germ layers or future segments. Evidently, stripe expression of the zygotic genes is among the key mechanisms of embryo patterning. In this paper, known qualitative and quantitative models for the stripe formation are considered on the example of early embryogenesis of Drosophila . The current model analysis emphasizes the role of spatial information flow in development. Discussion is given on frequent network motifs, pointing to spatial stripe formation solutions.