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Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?
Author(s) -
Copland John A.,
SheffieldMoore Melinda,
KoldzicZivanovic Nina,
Gentry Sean,
Lamprou George,
TzortzatouStathopoulou Fotini,
Zoumpourlis Vassilis,
Urban Randall J.,
Vlahopoulos Spiros A.
Publication year - 2009
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.200800138
Subject(s) - receptor , biology , microbiology and biotechnology , steroid , endocrinology , hormone , genetics
Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with the glucocorticoid receptor and other factors essential to cell fate. Interactions of steroid receptor domain motifs with heterologous proteins affect specific target pathways; consequently, manipulation of specified protein modules complexed with steroid receptors may be a next major step for enhancing molecular targeted therapeutics. In the future, intervention at specific sections of receptor primary sequence may prove therapeutically more efficient in targeting pathways of choice than ligand selectivity can be.