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Growth and specification: fly Pax6 homologs eyegone and eyeless have distinct functions
Author(s) -
Rodrigues Aloma B.,
Moses Kevin
Publication year - 2004
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20055
Subject(s) - pax6 , biology , eye development , gene , rna splicing , genetics , alternative splicing , cell growth , encode , microbiology and biotechnology , messenger rna , computational biology , phenotype , rna , transcription factor
Abstract Development requires not only the correct specification of organs and cell types in the right places (pattern), but also the control of their size and shape (growth). Many signaling pathways control both pattern and growth and how these two are distinguished has been something of a mystery. In the fly eye, a Pax6 homolog ( eyeless ) controls eye specification together with several other genes. Now Dominguez et al.1 show that Notch signaling controls eye growth through a second Pax6 protein (Eyegone). In mice and humans the single Pax6 gene appears to encode both specification and growth controlling proteins through alternative mRNA splicing. BioEssays 26:600–603, 2004. © 2004 Wiley Periodicals, Inc.