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Rac1 and Rac2 GTPases in haematopoiesis
Author(s) -
Weston Victoria J.,
Stankovic Tatjana
Publication year - 2004
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20017
Subject(s) - haematopoiesis , rac1 , biology , gtpase , gene , microbiology and biotechnology , rac gtp binding proteins , genetics , immunology , stem cell , signal transduction
The highly homologous Rac1 and Rac2 GTPases are co‐expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity. BioEssays 26:221–224, 2004. © 2004 Wiley Periodicals, Inc.