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Making a vertebrate limb: New players enter from the wings
Author(s) -
Martin Gail
Publication year - 2001
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.1126
Subject(s) - vertebrate , fibroblast growth factor , fgf10 , limb development , biology , wnt signaling pathway , fgf8 , evolutionary biology , gene , limb bud , zone of polarizing activity , anatomy , microbiology and biotechnology , genetics , embryonic stem cell , mesoderm , receptor
What initiates vertebrate limb development and induces limbs to form where they do? For several years the answer to this intriguing question has been framed in terms of a working model that limb induction depends on a dialogue between two members of the Fibroblast Growth Factor (FGF) family of intercellular signaling molecules, FGF8 and FGF10. Now, a recent paper has written roles for signals encoded by WNT genes, the vertebrate relatives of the Drosophila wingless gene, into the script.(1) BioEssays 23:865–868, 2001. © 2001 John Wiley & Sons, Inc.
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