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The next step in systems biology: simulating the temporospatial dynamics of molecular network
Author(s) -
Zhu Hao,
Huang Sui,
Dhar Pawan
Publication year - 2004
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10383
Subject(s) - dependency (uml) , gene regulatory network , context (archaeology) , computational biology , systems biology , organism , computer science , network dynamics , biology , molecular dynamics , dynamics (music) , model organism , gene , topology (electrical circuits) , genetics , gene expression , artificial intelligence , physics , engineering , paleontology , mathematics , discrete mathematics , quantum mechanics , acoustics , electrical engineering
Abstract As a result of the time‐ and context‐dependency of gene expression, gene regulatory and signaling pathways undergo dynamic changes during development. Creating a model of the dynamics of molecular interaction networks offers enormous potential for understanding how a genome orchestrates the developmental processes of an organism. The dynamic nature of pathway topology calls for new modeling strategies that can capture transient molecular links at the runtime. The aim of this paper is to present a brief and informative, but not all‐inclusive, viewpoint on the computational aspects of modeling and simulation of a non‐static molecular network. BioEssays 26:68–72, 2004. © 2003 Wiley Periodicals, Inc.