Premium
Starting the protein synthesis machine: eukaryotic translation initiation
Author(s) -
Preiss Thomas,
W. Hentze Matthias
Publication year - 2003
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10362
Subject(s) - eukaryotic translation , eukaryotic translation initiation factor 4 gamma , eif4ebp1 , translation (biology) , protein biosynthesis , eif4a1 , proteome , eif4e , computational biology , eukaryotic initiation factor , transcriptome , biology , initiation factor , messenger rna , microbiology and biotechnology , gene , gene expression , genetics
Abstract The final assembly of the protein synthesis machinery occurs during translation initiation. This delicate process involves both ends of eukaryotic messenger RNAs as well as multiple sequential protein–RNA and protein–protein interactions. As is expected from its critical position in the gene expression pathway between the transcriptome and the proteome, translation initiation is a selective and highly regulated process. This synopsis summarises the current status of the field and identifies intriguing open questions. BioEssays 25:1201–1211, 2003 © 2003 Wiley Periodicals, Inc.