Premium
Human severe combined immune deficiency and DNA repair
Author(s) -
Schwarz Klaus,
Ma Yunmei,
Pannicke Ulrich,
Lieber Michael R.
Publication year - 2003
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10344
Subject(s) - immune system , biology , genetics , non homologous end joining , dna , dna repair , gene , genetic enhancement , immunology
Human severe combined immune deficiency (SCID) is the most serious inherited immunological deficit. Recent work has revealed defects in the predominant pathway for double‐strand break repair called nonhomologous DNA end joining, or NHEJ. Progress in the biochemistry and genetics of NHEJ and of human SCID has proven to be synergistic between these two fields in a manner that covers the range from biochemical etiology to considerations about possible gene therapy for the B − SCID patients. BioEssays 25:1061–1070, 2003. © 2003 Wiley Periodicals, Inc.