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Idiomatic (gene) expressions
Author(s) -
Rockman Matthew V.
Publication year - 2003
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10279
Subject(s) - gene , biology , genetics , computational biology , coding region , phenotype , identification (biology) , regulatory sequence , coding (social sciences) , genetic variation , single nucleotide polymorphism , variation (astronomy) , evolutionary biology , regulation of gene expression , genotype , statistics , botany , mathematics , physics , astrophysics
Hidden among the myriad nucleotide variants that constitute each species' gene pool are a few variants that contribute to phenotypic variation. Many of these differences that make a difference are non‐coding cis ‐regulatory variants, which, unlike coding variants, can only be identified through laborious experimental analysis. Recently, Cowles et al.1 described a screening method that does an end‐run around this problem by searching for genes whose cis regulation varies without having to find the polymorphic nucleotides that influence transcription. While we will continue to require a diverse arsenal of experimental methods, this versatile method will speed the identification of functional genetic variation. BioEssays 25:421–424, 2003. © 2003 Wiley Periodicals, Inc.