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Topoisomerase II may be linked to the reduction of chromosome number in meiosis
Author(s) -
Paliulis Leocadia V.,
Nicklas R. Bruce
Publication year - 2003
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10265
Subject(s) - meiosis , biology , kinetochore , chromosome segregation , ploidy , topoisomerase , chromosome , cohesin , genetics , chromosome number , genome , dna , microbiology and biotechnology , karyotype , gene
A reduction of chromosome number in meiosis is essential for genome transmission in diploid organisms. Reduction depends on a change in kinetochore configuration.1 A recent study2 connects changes in kinetochores with other changes in chromosome structure and raises the intriguing possibility that topoisomerase II, the DNA untangling enzyme, is involved. BioEssays 25:309–312, 2003. © 2003 Wiley Periodicals, Inc.