Topoisomerase II may be linked to the reduction of chromosome number in meiosis | Zendy

Paliulis Leocadia V. | Zendy; Nicklas R. Bruce | Zendy

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Topoisomerase II may be linked to the reduction of chromosome number in meiosis

Author(s) -

Paliulis Leocadia V.,

Nicklas R. Bruce

Publication year - 2003

Publication title -

bioessays

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.175

H-Index - 184

eISSN - 1521-1878

pISSN - 0265-9247

DOI - 10.1002/bies.10265

Subject(s) - meiosis , biology , kinetochore , chromosome segregation , ploidy , topoisomerase , chromosome , cohesin , genetics , chromosome number , genome , dna , microbiology and biotechnology , karyotype , gene

A reduction of chromosome number in meiosis is essential for genome transmission in diploid organisms. Reduction depends on a change in kinetochore configuration.1 A recent study2 connects changes in kinetochores with other changes in chromosome structure and raises the intriguing possibility that topoisomerase II, the DNA untangling enzyme, is involved. BioEssays 25:309–312, 2003. © 2003 Wiley Periodicals, Inc.

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