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Trans ‐splicing in Drosophila
Author(s) -
Pirrotta Vincenzo
Publication year - 2002
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10182
Subject(s) - rna splicing , exon , trans splicing , primary transcript , biology , gene , alternative splicing , genetics , rna , gene isoform , intron , coding region , exonic splicing enhancer , non coding rna , computational biology
Splicing is an efficient and precise mechanism that removes noncoding regions from a single primary RNA transcript. Cutting and rejoining of the segments occurs on nascent RNA. Trans ‐splicing between small specialized RNAs and a primary transcript has been known in some organisms but recent papers show that trans ‐splicing between two RNA molecules containing different coding regions is the normal mode in a Drosophila gene.1–3 The mod(mdg4) gene produces 26 different mRNAs encoding as many protein isoforms. The differences lie in alternative 3′ exons encoded by different transcriptional units and spliced to the 5′ common region by a surprising trans ‐splicing mechanism. BioEssays 24:988–991, 2002. © 2002 Wiley‐Periodicals, Inc.