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Non‐stop decay—a new mRNA surveillance pathway
Author(s) -
Vasudevan Shobha,
Peltz Stuart W.,
Wilusz Carol J.
Publication year - 2002
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10153
Subject(s) - messenger rna , biology , nonsense mediated decay , ribosome , transcription (linguistics) , gene , genetics , gene expression , stop codon , computational biology , microbiology and biotechnology , rna , rna splicing , linguistics , philosophy
Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several surveillance mechanisms have evolved to check the fidelity at each step of mRNA manufacture. Two recent reports describe the identification of a novel pathway in eukaryotes that recognizes and degrades mRNAs that lack a stop codon.1,2 The non‐stop decay mechanism releases ribosomes stalled at the 3′ end of a mRNA and stimulates the exosome to rapidly degrade the transcript. BioEssays 24:785–788, 2002. © 2002 Wiley Periodicals, Inc.