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Growth, hedgehog and the price of GAS
Author(s) -
Mullor José L.,
Ruiz i. Altaba Ariel
Publication year - 2002
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10052
Subject(s) - sonic hedgehog , hedgehog signaling pathway , biology , hedgehog , gene , function (biology) , microbiology and biotechnology , embryonic stem cell , signal transduction , genetics
Embryonic development in a given species is orchestrated by genes regulating growth and differentiation in a stereotyped and conserved manner, resulting in embryos of consistent size and shape. Several signaling pathways, including that of Sonic Hedgehog (SHH), have been implicated in these processes. Recent experiments with Gas1 indicate that it may act as a growth‐inducing gene, challenging its previous function as a gene specifically involved in growth arrest. Moreover, GAS1, a GPI‐linked membrane protein, can bind SHH, suggesting an interacting link between growth and patterning through SHH and GAS1.(1–4) BioEssays 24:22–26, 2002. © 2002 John Wiley & Sons, Inc.