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Integrin control of cell cycle: a new role for ubiquitin ligase
Author(s) -
Pu Qing Qiu,
Streuli Charles H.
Publication year - 2002
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10049
Subject(s) - ubiquitin ligase , microbiology and biotechnology , integrin linked kinase , integrin , biology , signal transduction , cell cycle , ubiquitin , kinase , chemistry , cell , cyclin dependent kinase 2 , biochemistry , protein kinase a , gene
Receptor tyrosine kinases and integrins are activated by growth factors and extracellular matrix, respectively. Their activation leads to signal transduction cascades that control many aspects of cell phenotype, including progression through the G 1 phase of the cell cycle. However, the signalling cassettes driven by growth factors and matrix do not work independently of each other. Integrin triggering is essential to facilitate kinase‐ and GTPase‐mediated signals and thereby drive efficient transfer of information through the growth factor–cyclin axis. A recent study indicates that an additional type of player has a key role in adhesion‐regulated control of cell cycle, namely ubiquitin ligase.(1) BioEssays 24:17–21, 2002. © 2002 John Wiley & Sons, Inc.