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Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins
Author(s) -
Rahmouni Kamal,
Haynes William G.
Publication year - 2001
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.10018
Subject(s) - leptin , melanocortins , hypothalamus , endocrinology , medicine , neuropeptide , appetite , proopiomelanocortin , melanocortin , biology , neuropeptide y receptor , hormone , central nervous system , adipose tissue , leptin receptor , neuroscience , obesity , receptor
Abstract No other hormone has drawn more attention than leptin in recent studies on the control of appetite, body weight and obesity. This hormone is produced by adipose tissue and enters the brain via a saturable specific transport mechanism. Leptin acts in the hypothalamus to modulate food intake and heat production as well as several other neuroendocrine pathways. The mechanisms through which leptin exerts its central nervous effects are now better understood. Proopiomelanocortin‐ and neuropeptide Y‐containing neurons in the hypothalamus have emerged as potent candidate mediators of leptin action. These two neuropeptides have been shown to exert opposing effects using different pathways. Recently, Cowley et al. (2001) described a new circuit in the regulation of neuronal activity by leptin with an interaction between these two pathways. These data add complexity to the mechanisms by which leptin achieves its effects in the central nervous system, but they also offer potential mechanisms to explain the phenomenon of leptin resistance observed in obesity. BioEssays 23:1095–1099, 2001. © 2001 John Wiley & Sons, Inc.