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Effect of magnetic fields on rodent monooxygenase enzymes
Author(s) -
Carratore R. Del,
Morichetti E.,
Della Croce C.,
Bronzetti G.
Publication year - 1995
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250160509
Subject(s) - rodent , rodent model , enzyme , monooxygenase , biology , ecology , biochemistry , cytochrome p450 , endocrinology
The effects of 50 Hz, 1.2 mT magnetic fields (MFs) were tested on hepatic monooxygenase enzymes of basal and β‐naphthoflavone‐phenobarbital‐preinduced rats and mice. An inductive effect on cytochrome P‐450 level and on some enzymatic cytochrome P‐450‐dependent activities was observed in basal mice after MF exposure. Enzymatic activities in preinduced mice and rats were reduced by MFs, the degree of reduction depending on the enzyme. A specific inhibitory effect was determined in some of the assayed activities and in the relative peculiar P‐450 isoforms detected by Western blot analysis. © 1995 Wiley‐Liss, Inc.