Premium
Exposure of simian virus‐40‐transformed human cells to magnetic fields results in increased levels of T‐antigen mRNA and protein
Author(s) -
Gold Steven,
Goodman Reba,
ShirleyHenderson Ann
Publication year - 1994
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250150407
Subject(s) - messenger rna , biology , antigen , dna , gene , genome , endogeny , virus , microbiology and biotechnology , gene expression , virology , genetics , endocrinology
In its integrated form, SV‐40 DNA offers an opportunity to observe the behavior of what is in effect a viral genome within a cellular genome, with transcriptional and translational products that can be clearly distinguished from those of the host cell. Exposure of SV40‐transformed human fibroblasts to a 60 Hz continuous‐wave sinusoidal electromagnetic (EM) field resulted in increased levels of virally derived mRNA and protein of large T‐antigen. These findings provide evidence that a foreign DNA integrated into cells can be affected by EM fields under conditions known to cause increased transcripts from endogenous cellular genes. © 1994 Wiley‐Liss, Inc.