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Effects of a 60 Hz magnetic field on central cholinergic systems of the rat
Author(s) -
Lai H.,
Carino M. A.,
Horita A.,
Guy A. W.
Publication year - 1993
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250140104
Subject(s) - naltrexone , (+) naloxone , antagonist , endogenous opioid , narcotic antagonist , central nervous system , opioid antagonist , cholinergic , hippocampus , choline , neuroscience , opioid receptor , endocrinology , chemistry , medicine , opioid , receptor , biology
We studied the effects of an acute (45 min) exposure to a 60 Hz magnetic field on sodium‐dependent, high‐affinity choline uptake in the brain of the rat. Decreases in uptake were observed in the frontal cortex and hippocampus after the animals were exposed to a magnetic field at flux densities ≫ 0.75 mT. These effects of the magnetic field were blocked by pretreating the animals with the narcotic antagonist naltrexone, but not by the peripheral opioid antagonist, naloxone methiodide. These data indicate that the magnetic‐field‐induced decreases in high‐affinity choline uptake in the rat brain were mediated by endogenous opioids in the central nervous systems. © 1993 Wiley‐Liss, Inc.