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Threshold for inhibition of Na, K‐ATPase by ELF alternating currents
Author(s) -
Blank Martin,
Soo Lily
Publication year - 1992
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250130409
Subject(s) - electric field , alternating current , enzyme , atpase , chemistry , biophysics , physics , range (aeronautics) , enzyme assay , current density , nuclear magnetic resonance , materials science , biology , voltage , quantum mechanics , composite material
Alternating currents can increase or decrease the ATP‐splitting activity of the membrane enzyme Na,K‐ATPase. Either change depends on the AC frequency, and the greatest effect appears to be in the ELF range at about 100 Hz. The threshold for enzyme inhibition by AC was determined, and it is estimated to be an internal electric field circa 5 μV/cm. The corresponding current‐density threshold approximates 8 nA/cm 2 . 1992 Wiley‐Liss, Inc.