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Blood‐brain barrier permeation in the rat during exposure to low‐power 1.7‐GHz microwave radiation
Author(s) -
Ward T. R.,
Ali J. S.
Publication year - 1985
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250060205
Subject(s) - microwave , pentobarbital , chemistry , absorption (acoustics) , inulin , blood–brain barrier , irradiation , specific absorption rate , ignitor , permeability (electromagnetism) , pulse (music) , nuclear magnetic resonance , biophysics , materials science , anesthesia , medicine , central nervous system , biology , optics , computer science , composite material , telecommunications , biochemistry , quantum mechanics , physics , antenna (radio) , membrane , detector , ignition system , nuclear physics , thermodynamics
The permeability of the blood‐brain barrier to high‐ and low‐molecular‐weight compounds has been measured as a function of continuous‐wave (CW) and pulsed‐microwave radiation. Adult rats, anesthetized with pentobarbital and injected intravenously with a mixture of [ 14 C] sucrose and [ 3 H] inulin, were exposed for 30 min at a specific absorption rate of 0.1 W/kg to 1.7‐GHz CW and pulsed (0.5‐μs pulse width, 1,000 pps) microwaves. After exposure, the brain was perfused and sectioned into nine regions, and the radioactivity in each region was counted. During identical exposure conditions, temperatures of rats were measured in eight of the brain regions by a thermistor probe that did not perturb the field. No change in uptake of either tracer was found in any of the eight regions as compared with those of sham‐exposed animals.