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Low frequency amplitude modulated microwave fields change calcium efflux rates from synaptosomes
Author(s) -
LinLiu S.,
Adey W. R.
Publication year - 1982
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250030303
Subject(s) - efflux , calcium , amplitude , microwave , chemistry , biophysics , phase (matter) , analytical chemistry (journal) , nuclear magnetic resonance , materials science , chromatography , biochemistry , optics , physics , biology , organic chemistry , quantum mechanics
Calcium( 45 Ca 2 + ) efflux from preloaded synaptosomes was studied with a continuous perfusion technique and the rate constants of a two‐phase efflux process calculated. When 16‐Hz sinusoidally amplitude modulated 450‐MHz microwave field (maximal incident intensity 0.5 mW/ cm 2 , modulation depth 75%) was applied during the second phase, the rate constant increased by 38%. Unmodulated or 60‐Hz modulated signals were not effective. This microwave fieldinduced change can be distinguished from CaCl 2 ‐stimulated 45 Ca 2 + efflux which is most probably derived intracellularly. These data suggest that the microwave‐field‐induced change in calcium efflux probably did not involve intracellular calcium. Also, this change in the dynamic property of synaptosomes did not require gross anatomically intact tissue as a substrate for field tissue interaction.