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Microwave treatment of intracerebral l1210 leukemia: Schedule‐dependent partial reversal of the effects of methotrexate
Author(s) -
Chang Barbara K.,
Huang Andrew T.,
Joines William T.
Publication year - 1981
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.2250020109
Subject(s) - methotrexate , leukemia , medicine , pharmacology , central nervous system
One‐GHz microwave (MW) irradiation at a power density of 5 mW/cm 2 was combined with methotrexate (MTX) in an attempt to treat more effectively central nervous system (CNS) L1210 leukemia in DBA/2J mice. When mice with CNS leukemia were treated with the combination of MW and MTX, there was no improvement in survival compared with a group of animals treated with MTX alone; however, the group that received MTX before the MW exposure had a significantly reduced survival time compared with the group treated with MTX alone or with the group to which MTX was administered after MW.