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Static Magnetic Field Versus Systemic Calcium Channel Blockade Effect on Microcirculation: Possible Mechanisms and Clinical Implementation
Author(s) -
Gmitrov Juraj
Publication year - 2020
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.22272
Subject(s) - microcirculation , vasodilation , medicine , plethysmograph , blood flow , nitric oxide , anesthesia , cardiology
The goal was to compare static magnetic field (SMF, generated by Nd 2 –Fe 14 –B magnets) vasodilator capacity with verapamil (VER, a potent, clinically verified Ca 2+ channel‐blocking agent), aimed to assess SMF implementation in conditions with vascular ischemia. Skin microcirculatory blood flow measured by microphotoelectric plethysmogram was recorded in conscious rabbits after 40 min of 0.25 T SMF regional exposure to ear microvascular net (SMF‐Vas, n = 20), or 0.35 T to carotid baroreceptors (SMF‐Car, n = 14), and compared with that after 30 min VER intravenous infusion (20 µg/kg/min, n = 20). The principal finding is that SMF‐Vas, SMF‐Car, and VER significantly increased microcirculatory blood flow by 17.9 ± 9.58%, 22.6 ± 11.11%, and 30.5 ± 14.06% (mean ± SEM) respectively, and there was no significant difference between all three treatments ( P = 0.986). Microvascular dilation was accompanied by significant decrease of blood pressure in VER and SMF‐Car cases. The decrease of arterial baroreflex sensitivity in VER contrasted with its increase in SMF‐Car, coupled with improved vessel sensitivity to nitric oxide (NO) dilatory effect. This suggests that SMF can have a strong vasodilator property tailored to address diabetic, mainly NO‐deficient, neural, and myogenic microvascular dysfunction, especially employing both SMFs’ vasodilation synergy. Bioelectromagnetics. 2020;41:447–457. © 2020 Bioelectromagnetics Society.