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A new theoretical model for transmembrane potential and ion currents induced in a spherical cell under low frequency electromagnetic field
Author(s) -
Zheng Yu,
Gao Yang,
Chen Ruijuan,
Wang Huiquan,
Dong Lei,
Dou Junrong
Publication year - 2016
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.21993
Subject(s) - bioelectromagnetics , current (fluid) , nernst equation , ionic bonding , laplace transform , cable theory , ion , ion current , electromagnetic field , work (physics) , membrane potential , physics , transmembrane protein , electric potential , chemistry , biophysics , voltage , mathematics , thermodynamics , mathematical analysis , quantum mechanics , electrical engineering , engineering , biology , cable gland , cable harness , receptor , biochemistry , electrode
Time‐varying electromagnetic fields (EMF) can induce some physiological effects in neuronal tissues, which have been explored in many applications such as transcranial magnetic stimulation. Although transmembrane potentials and induced currents have already been the subjects of many theoretical studies, most previous works about this topic are mainly completed by utilizing Maxwell's equations, often by solving a Laplace equation. In previous studies, cells were often considered to be three‐compartment models with different electroconductivities in different regions (three compartments are often intracellular regions, membrane, and extracellular regions). However, models like that did not take dynamic ion channels into consideration. Therefore, one cannot obtain concrete ionic current changes such as potassium current change or sodium current change by these models. The aim of the present work is to present a new and more detailed model for calculating transmembrane potentials and ionic currents induced by time‐varying EMF. Equations used in the present paper originate from Nernst‐Plank equations, which are ionic current‐related equations. The main work is to calculate ionic current changes induced by EMF exposure, and then transmembrane potential changes are calculated with Hodgkin‐Huxley model. Bioelectromagnetics. 37:481–492, 2016. © 2016 Wiley Periodicals, Inc.