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Theoretical analysis of AC electric field transmission into biological tissue through frozen saline for electroporation
Author(s) -
Xiao Chunyan,
Rubinsky Boris
Publication year - 2014
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.21881
Subject(s) - electroporation , electric field , biomedical engineering , materials science , saline , chemistry , medicine , physics , biochemistry , quantum mechanics , gene
An analytical model was used to explore the feasibility of sinusoidal electric field transmission across a frozen saline layer into biological tissue. The study is relevant to electroporation and permeabilization of the cell membrane by electric fields. The concept was analyzed for frequencies in the range of conventional electroporation frequencies and electric field intensity. Theoretical analysis for a variety of tissues show that the transmission of electroporation type electric fields through a layer of frozen saline into tissue is feasible and the behavior of this composite system depends on tissue type, frozen domain temperature, and frequency. Freezing could become a valuable method for adherence of electroporation electrodes to moving tissue surfaces, such as the heart in the treatment of atrial fibrillation or blood vessels for the treatment of restenosis. Bioelectromagnetics 35:607–613, 2014. © 2014 Wiley Periodicals, Inc.