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Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease
Author(s) -
Del Vecchio Giovanna,
Giuliani Alessandro,
Fernandez Mercedes,
Mesirca Pietro,
Bersani Ferdinando,
Pinto Rosanna,
Ardoino Lucia,
Lovisolo Giorgio A.,
Giardino Luciana,
Calzà Laura
Publication year - 2009
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.20507
Subject(s) - specific absorption rate , viability assay , cholinergic , glutamate receptor , neuroscience , bioelectromagnetics , in vitro , hydrogen peroxide , neuroprotection , chemistry , microbiology and biotechnology , biology , electromagnetic field , medicine , biophysics , physics , biochemistry , telecommunications , computer science , receptor , quantum mechanics , antenna (radio)
Abstract In this work we tested viability, proliferation, and vulnerability of neural cells, after continuous radiofrequency (RF) electromagnetic fields exposure (global system for mobile telecommunications (GSM) modulated 900 MHz signal at a specific absorption rate (SAR) of 1 W/kg and maximum duration 144 h) generated by transverse electromagnetic cells. We used two cellular systems, SN56 cholinergic for example, SN56 cholinergic cell line and rat primary cortical neurons, and well‐known neurotoxic challenges, such as glutamate, 25‐35AA beta‐amyloid, and hydrogen peroxide. Exposure to RF did not change viability/proliferation rate of the SN56 cholinergic cells or viability of cortical neurons. Co‐exposure to RF exacerbated neurotoxic effect of hydrogen peroxide in SN56, but not in primary cortical neurons, whereas no cooperative effects of RF with glutamate and 25‐35AA beta‐amyloid were found. These data suggest that only under particular circumstances exposure to GSM modulated, 900 MHz signal act as a co‐stressor for oxidative damage of neural cells. Bioelectromagnetics 30:564–572, 2009. © 2009 Wiley‐Liss, Inc.