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Acute exposure to low‐level CW and GSM‐modulated 900 MHz radiofrequency does not affect Ba 2+ currents through voltage‐gated calcium channels in rat cortical neurons
Author(s) -
Platano Daniela,
Mesirca Pietro,
Paffi Alessandra,
Pellegrino Monica,
Liberti Micaela,
Apollonio Francesca,
Bersani Ferdinando,
Aicardi Giorgio
Publication year - 2007
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.20345
Subject(s) - gsm , specific absorption rate , radio frequency , amplitude , voltage , materials science , electrophysiology , bioelectromagnetics , calcium , nuclear magnetic resonance , chemistry , electromagnetic field , medicine , physics , electrical engineering , telecommunications , optics , quantum mechanics , computer science , antenna (radio) , engineering
We have studied the non‐thermal effects of radiofrequency (RF) electromagnetic fields (EMFs) on Ba 2+ currents ( $I_{{\rm Ba}^{2+ } }$ ) through voltage‐gated calcium channels (VGCC), recorded in primary cultures of rat cortical neurons using the patch‐clamp technique. To assess whether low‐level acute RF field exposure could modify the amplitude and/or the voltage‐dependence of $I_{{\rm Ba}^{2+ } }$ , Petri dishes containing cultured neurons were exposed for 1–3 periods of 90 s to 900 MHz RF‐EMF continuous wave (CW) or amplitude‐modulated according to global system mobile communication standard (GSM) during whole‐cell recording. The specific absorption rates (SARs) were 2 W/kg for CW and 2 W/kg (time average value) for GSM‐modulated signals, respectively. The results obtained indicate that single or multiple acute exposures to either CW or GSM‐modulated 900 MHz RF‐EMFs do not significantly alter the current amplitude or the current–voltage relationship of $I_{{\rm Ba}^{2+ } }$ , through VGCC. Bioelectromagnetics 28:599–607, 2007. © 2007 Wiley‐Liss, Inc.