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Effects of a 50 Hz electric field on plasma lipid peroxide level and antioxidant activity in rats
Author(s) -
Harakawa Shinji,
Inoue Noboru,
Hori Takuya,
Tochio Koji,
Kariya Tatsuya,
Takahashi Kunihito,
Doge Fuyuki,
Suzuki Hiroshi,
Nagasawa Hideyuki
Publication year - 2005
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.20137
Subject(s) - lipid peroxide , superoxide dismutase , ascorbic acid , antioxidant , chemistry , peroxide , oxidizing agent , lipid peroxidation , medicine , biochemistry , endocrinology , food science , organic chemistry
The effects of exposure to extremely low frequency electric fields (ELF EFs) on plasma lipid peroxide levels and antioxidant activity (AOA) in Sprague–Dawley rats were studied. The test was based on comparisons among rats treated with a combination of the oxidizing agent, 2,2′‐azobis(2‐aminopropane) dihydrochloride (AAPH) and 50 Hz EF of 17.5 kV/m intensity for 15 min per day for 7 days, AAPH alone, EF alone or no treatment. EF significantly decreased the plasma peroxide level in rats treated with AAPH, similar to treatment by ascorbic acid or the superoxide dismutase. Ascorbic acid increased AOA; however, EF and superoxide dismutase did not change AOA compared with sham exposure in stressed rats. No influence on the lipid peroxide level and AOA in unstressed rats was observed with EF exposure alone. Although the administration of AAPH decreased AOA, this decrease did not change when EF was added. These data indicate that the ELF EF used in this study influenced the lipid peroxide level in an oxidatively stressed rat. Bioelectromagnetics 26:589–594, 2005. © 2005 Wiley‐Liss, Inc.