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Neuronal outgrowth of PC‐12 cells after combined treatment with nerve growth factor and a magnetic field: Influence of the induced electric field strength
Author(s) -
Schimmelpfeng J.,
Weibezahn K.F.,
Dertinger H.
Publication year - 2005
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.20073
Subject(s) - neurite , nerve growth factor , magnetic field , field strength , neuroscience , field (mathematics) , electric field , biology , physics , medicine , in vitro , mathematics , receptor , biochemistry , quantum mechanics , pure mathematics
In view of possible therapeutic applications of magnetic fields, the effect of an enhancement of neuronal outgrowth at higher figures of flux density and induced field strength was investigated. On the average sinusoidal magnetic field treatment at 100 μT rms /50 Hz did not change nerve growth factor (NGF) induced neurite outgrowth to a statistically significant extent. These results suggest that further increasing the induced field strength by using either higher flux densities and/or more sophisticated wave forms might be necessary to cause the neuronal response of PC‐12 cells, as seen in other experiments. Bioelectromagnetics 26:74–77, 2005. © 2004 Wiley‐Liss, Inc.