Premium
Effects of 50 Hz magnetic fields on fMLP‐induced shape changes in invertebrate immunocytes: The role of calcium ion channels
Author(s) -
Gobba Fabriziomaria,
Malagoli Davide,
Ottaviani Enzo
Publication year - 2003
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.10102
Subject(s) - verapamil , mytilus , chemistry , voltage dependent calcium channel , ion channel , biophysics , calcium , chemotaxis , channel blocker , membrane potential , biology , biochemistry , receptor , fishery , organic chemistry
Plasma membrane Ca 2+ channels in immunocytes from the mussel Mytilus galloprovincialis exposed to 50 Hz sine wave magnetic fields (MFs) of various strengths were studied. At levels of 300 μT and above, MFs reduce shape changes in immunocytes induced by the chemotactic substance N ‐formyl‐Meth‐Leu‐Phe, and this effect involves L‐type Ca 2+ channels. Upon the addition of the Ca 2+ blocker verapamil to molluscan immunocytes exposed to MFs results in a synergistic cytotoxic action, while in the presence of the Ca 2+ opener SDZ‐202, 791, a reactivation of the cells is observed. This suggests that, as previously reported for potassium channels, the damage to Ca 2+ channels induced by short exposure to MF at appropriate intensities is not permanent. Bioelectromagnetics 24:277–282, 2003. © 2003 Wiley‐Liss, Inc.