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Ultra‐wideband pulses increase nitric oxide production by RAW 264.7 macrophages incubated in nitrate * †
Author(s) -
Seaman Ronald L.,
Parker Jill E.,
Kiel Johnathan L.,
Mathur Satnam P.,
Grubbs Teri R.,
Prol H. Kenneth
Publication year - 2002
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/bem.100
Subject(s) - nitric oxide , lipopolysaccharide , nitrite , nitrate , chemistry , nitric oxide synthase , medicine , organic chemistry
Abstract The possible effects of ultra‐wideband (UWB) pulses on cellular nitric oxide production were tested by measuring nitrite in the medium bathing UWB exposed RAW 264.7 macrophages. A 30 min exposure to 1 ns UWB pulses, repeated at 600 Hz with an estimated SAR of 0.106 W/kg, did not change nitric oxide production by RAW 264.7 cells, with or without stimulation by gamma interferon and lipopolysaccharide. However, when nitrate was added to the medium of stimulated cells, nitric oxide production increased after UWB exposure, indicating a possible action of UWB pulses on induced nitric oxide synthase under certain conditions. Bioelectromagnetics 23:83–87, 2002. © 2002 Wiley‐Liss, Inc.